Study: Vitamin D derivatives hold benefits for photoaging & skin protection

A study published in Cosmetics found that hydroxyderivatives of vitamin D can act as antioxidants, helping to protect skin against some of the effects of UV exposure and aging. The authors analyzed previous reports on vitamin D derivatives and skin protection.

Impact on different skin cell types

Novel vitamin D derivatives are also involved in DNA repair, can reduce oxidative stress, and improve wound healing processes, among other functions. 

Vitamin D metabolites have previously been used to treat skin conditions, including psoriasis—by inhibiting keratinocyte proliferation—and alopecia—by acting as a hair growth stimulant. 

Vitamin D derivatives act on several different skin cells to create these benefits. In keratinocytes, they have anti-inflammatory properties, inhibit DNA damage and help to stimulate DNA repair after UV exposure. “They also reduce the levels of H2O2 and NO and increase the levels of detoxifying enzymes, such as GSH, thus enhancing DNA repair similarly to melatonin,” the authors write.

In melanocytes, the derivatives help to inhibit apoptosis and act as antioxidants. 

For fibroblasts, they promote wound healing and regeneration. Vitamin D derivatives beneficially affect collagen production by repairing and replacing collagen and decreasing collagenase. In addition, the authors write that vitamin D3 partially regulates an anti-aging gene called alpha-Klotho. 

In addition, vitamin D derivatives can help heal wounds and prevent hypertrophic scars and systemic sclerosis. They can also regulate pro-inflammatory cytokines by increasing levels of anti-inflammatory cytokines. 

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